The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans.
Development
; 130(4): 693-704, 2003 Feb.
Article
em En
| MEDLINE
| ID: mdl-12506000
ABSTRACT
Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role of UNC-115 as a downstream cytoskeletal effector of Rac signaling in axon pathfinding. We show that unc-115 double mutants with ced-10 Rac, mig-2 Rac or unc-73 GEF but not with rac-2/3 Rac displayed synthetic axon pathfinding defects, and that loss of unc-115 function suppressed the formation of ectopic plasma membrane extensions induced by constitutively-active rac-2 in neurons. Furthermore, we show that UNC-115 can bind to actin filaments. Thus, UNC-115 is an actin-binding protein that acts downstream of Rac signaling in axon pathfinding.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Actinas
/
Caenorhabditis elegans
/
Proteínas rac de Ligação ao GTP
/
Proteínas de Caenorhabditis elegans
/
Proteínas dos Microfilamentos
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article