The preparation of a fully differentiated "multiwarhead" siderophore precursor.
J Org Chem
; 68(1): 191-4, 2003 Jan 10.
Article
em En
| MEDLINE
| ID: mdl-12515482
ABSTRACT
A protected, fully differentiated siderophore analogue has been prepared so that "Trojan Horse"-like siderophore drug conjugates with different drugs can be synthesized. The key steps in the synthesis include controlled preparation of an unsymmetrical urea and its conversion to a fully differentiated isocyanurate by reaction with chloro(carbonyl) isocyanate.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Sideróforos
/
Técnicas de Química Combinatória
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article