Evaluating the in vitro adhesive strength of biomaterials. Biosimulator for selective leak closure.
Biomaterials
; 24(8): 1469-75, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12527288
ABSTRACT
AIMS:
Surgical measures always involve problems of hemostasis and tissue management. Tissue sealing can be carried out in this case, with knowledge of the adhesive strength of liquid and fleece-bound sealing being of great clinical relevance. By employing a leak closure model, it has been possible to perform in vitro standardized technological-biomechanical experiments on a biomembrane mounted in a pressure chamber (biosimulator).FINDINGS:
Liquid sealing (fibrin gluing 4.1 hPa, photopolymerisate 82.9 hPa) offers minimal and maximal adhesive strengths. Fleece-bound sealing does not depend on the carrier material and is always more stabile than pure liquid sealing, whereby systems that must be coated "on the spot" (prepare-to-use 22.3-25.3 hPa) exhibit significantly lower adhesive strength (p < 0.0001) than a biodegradable collagen system, which is ready-to-use thanks to its fibrinogen-based coating (TachoComb H). Practicability, effectiveness and efficiency are further advantages of ready-to-use systems.CONCLUSIONS:
The biosimulator, presented here, is flexible in terms of its application for tissue management and it enables reproducible, economic and ecological evaluation of repair systems, e.g. tissue sealings.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adesivos Teciduais
/
Materiais Biocompatíveis
/
Teste de Materiais
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article