[Effectiveness of high-dose polychemotherapy and autologous hemopoietic cell transplantation in patients with low-grade non-Hodgkin lymphoma]. / Effektivnost' intensifikatsii polikhimioterapii i autologicheskoi transplantatsii gemopoéticheskikh kletok u bol'nykh nekhodzhkinskimi limfomami nizkoi stepeni zlokachestvennosti.

ABSTRACT

The study included 70 patients with high-grade malignant non-Hodgkin's lymphoma (Kiel) who received the following treatment group 1(24)--6-8 cycles of CHOP; group 2 (relapse or tumor progression after standard chemotherapy--13)--6 cycles of CHOP and Dexa-BEAM, and group 3 (relapse or tumor progression after standard chemotherapy--8)--6 cycles of CHOP plus Dexa-BEAM plus autologous hemopoietic cell transplantation with CBV or BEAM conditioning regimen (bone marrow or peripheral stem cells). The groups were comparable as far as gender and age are concerned. Overall 5-year survival rates were 81, 20 and 48%, respectively. CHOP-Dexa-BEAM plus autologous hemopoietic cell transplantation proved superior to CHOP-Dexa-BEAM alone.