The graded anxiety test: a novel test of murine unconditioned anxiety based on the principles of the elevated plus-maze and light-dark test.
J Neurosci Methods
; 122(1): 65-73, 2002 Dec 31.
Article
em En
| MEDLINE
| ID: mdl-12535765
ABSTRACT
Standard tests of murine unconditioned anxiety such as the elevated plus-maze and light-dark test are based on a dichotomy of avoidance behaviour (walled vs. open arms and dark vs. light compartments). We combined the principles of both tests by modifying the elevated plus-maze as follows one walled arm was made transparent and had a white floor (WTW), whereas the other walled arm was opaque-gray having a black floor (WOB). Furthermore, one open arm had a white floor (OW), while the other had a black one (OB). These modifications allow the distinction between more than two sub-compartments that elicit different degrees of avoidance behaviour, thus having a higher discriminative potency. Additionally, the paradigm was thought to permit the within-task detection of pharmacological side effects on the perception of the anxiogenic stimuli provided. The degree of avoidance of the sub-compartments exhibited by saline-treated mice for the distal parts of the four arms was distributed as follows WOB
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Psicologia Experimental
/
Psicofarmacologia
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Aprendizagem da Esquiva
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Comportamento Animal
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Diazepam
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article