Irreversible binding of o,p'-DDD in interrenal cells of Atlantic cod (Gadus morhua).
Chemosphere
; 50(9): 1249-53, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12547339
ABSTRACT
Precision-cut tissue slices of the anterior kidney from Atlantic cod (Gadus morhua) were prepared with a Krumdieck tissue slicer and exposed to 2-(2-chlorophenyl)-2-(4-chloro-(14C)phenyl)-1,1-dichlorethane (o,p(')-[14C]DDD) in vitro. Microautoradiography revealed irreversible o,p(')-DDD-derived binding confined to the glucocorticoid producing interrenal cells (adrenocortical analogues). This cell-selective binding was confirmed by means of autoradiography at different levels of resolution on Atlantic cod administered o,p(')-[14C]DDD intragastrically. The results provide evidence for a site-specific metabolic activation and irreversible binding of o,p(')-DDD in the interrenal cells, which, in turn, may modify glucocorticoid homeostasis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Inter-Renal
/
Rim
/
Mitotano
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article