The signature motif in human glucose-6-phosphate transporter is essential for microsomal transport of glucose-6-phosphate.
Hum Genet
; 112(4): 430-3, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12560945
ABSTRACT
Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate transporter (G6PT). Sequence alignments identify a signature motif shared by G6PT and a family of transporters of phosphorylated metabolites. Two null signature motif mutations have been identified in the G6PT gene of GSD-Ib patients. In this study, we characterize the activity of seven additional mutants within the motif. Five mutants lack microsomal G6P uptake activity and one retains residual activity, suggesting that in G6PT the signature motif is a functional element required for microsomal glucose-6-phosphate transport.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfotransferases
/
Doença de Depósito de Glicogênio Tipo I
/
Glucose-6-Fosfato
/
Microssomos
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article