Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors.
Farmaco
; 57(12): 989-92, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12564473
ABSTRACT
Starting from the random-screening hit 1a, a series of alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates 1 has been prepared. These derivatives turned out to be selective positive allosteric modulators of mGlu1 receptors. These compounds do not directly activate mGlu1 receptors but markedly potentiate agonist stimulated responses, increasing potency and maximum efficacy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tioxantenos
/
Xantenos
/
Proteínas Recombinantes
/
Receptores de Glutamato Metabotrópico
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article