Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse.
Cancer Res
; 36(4): 1353-60, 1976 Apr.
Article
em En
| MEDLINE
| ID: mdl-1260760
ABSTRACT
A variety of heterologous mammalian cells were inoculated into nude mice and scored for tumorigenicity. The cells tested were from primary cell cultures, established cell lines of neoplastic origin, established cell lines of nontumor origin, and primary cell cultures transformed by oncogenic viruses. Regardless of the animal species of origin, every cell line that was tumorigenic in some other animal host and every cell line of neoplastic origin was tumorigenic in nude mice. Several tissue culture cells lines capable of indefinite growth in vitro failed to form tumors in nude mice, and the basis of this growth suppression was investigated. The findings suggest that the failure of an established cell line to form tumors in nude mice is an authentic response to host-mediated growth-regulatory signals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Cultivadas
/
Vacinação
/
Camundongos Nus
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article