Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.
Bioorg Med Chem Lett
; 13(6): 1093-6, 2003 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-12643919
ABSTRACT
A series of 4'-[(imidazol-1-yl)methyl]biphenylsulfonamides has potent antagonist activity against both angiotensin II AT(1) and endothelin ET(A) receptors. Such dual-acting antagonists could have utility in the treatment of hypertension, heart failure, and other cardiovascular diseases in a broad patient population. Certain compounds in the present series are orally active in a rat model of angiotensin II-mediated hypertension.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Compostos de Bifenilo
/
Antagonistas de Receptores de Angiotensina
/
Antagonistas dos Receptores de Endotelina
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article