[Adverse effects of non-steroidal anti-inflammatory drugs. A prevalence study in Austria]. / Unerwünschte Wirkungen unter nichtsteroidalen Antiphlogistika. Eine Prävalenzstudie aus Osterreich.
Wien Klin Wochenschr
; 115(1-2): 41-6, 2003 Jan 31.
Article
em De
| MEDLINE
| ID: mdl-12658910
OBJECTIVE: Gastrointestinal side effects are the limiting factor in the prescription of non-steroidal antirheumatic drugs (NSAID). However, there are no recent data from Austria. The aim of this prevalence study was therefore to assess the gastrointestinal risk from NSAID in Austria. METHODS: A total of 1347 patients were observed in an outpatient setting between March 2000 and February 2001. Side effects from NSAID were documented by questionnaire at two time points with a mean interval of 31 days. Documented data were analysed descriptively using an explorative strategy. The prevalence of side effects was compared to data from literature. RESULTS: Side effects were reported by 18.1% of the patients, severe gastro-intestinal complications (ulcer, bleeding, perforation) were diagnosed in 0.7%. Prescription of effective GI-protection (proton pump inhibitors, misoprostole, famotidin in high dose) was seen in only one third of the patients at risk. CONCLUSION: The prevalence of severe gastrointestinal side effects by NSAIDs assessed in our study was clearly lower than the prevalence reported in the Anglo-American literature. This may be due to a different prescription behaviour: about 75% of the patients took Diclofenac, lbuprofen or Meloxicam, drugs which have a very low potential of gastrointestinal complications. However, more information for general practitioners is needed yet to sufficiently protect patients at gastrointestinal risk from NSAID.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Péptica Perfurada
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Úlcera Gástrica
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Úlcera Péptica Hemorrágica
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Anti-Inflamatórios não Esteroides
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Úlcera Duodenal
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
De
Ano de publicação:
2003
Tipo de documento:
Article