Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus.
Clin Infect Dis
; 36(8): 1070-3, 2003 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-12684922
ABSTRACT
We report 3 cases of renal toxicity associated with use of the antiviral agent tenofovir. Renal failure, proximal tubular dysfunction, and nephrogenic diabetes insipidus were observed, and, in 2 cases, renal biopsy revealed severe tubular necrosis with characteristic nuclear changes. Patients receiving tenofovir must be monitored closely for early signs of tubulopathy (glycosuria, acidosis, mild increase in the plasma creatinine level, and proteinuria).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Adenina
/
Diabetes Insípido Nefrogênico
/
Fármacos Anti-HIV
/
Insuficiência Renal
/
Síndrome de Fanconi
/
Organofosfonatos
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article