Immunotherapy and Immunorehabilitation in Clinic of Internal Diseases.

ABSTRACT

The choice of a preparation for selective correction and the solution to the question of how long immunotherapy should be carried out compose a complicated problem in view of the fact that in the majority of cases an attempt to treat any "main defect" of immune response in somatic patients is not possible. Immunomodulators by origin may be conditionally divided into endogenous and exogenous. Endogenous preparations combine interleukins, lymphokines, monokines, interferons, thymus hormones and some other substances which are present in a human organism and take part in the regulation of immune reactions. Use of this class of immunomodulators relates to a sufficiently wide spectrum of diseases, including of infectious and autoimmune pathology. Long-term fundamental studies of synthetic stimulators of immunity ended with the creation of a new immunomodulators - polyoxidonium, licopid and ribomunil. This preparations have a wide spectrum of immunopharmacological action. Of importance, from the point of view of clinical immunology, is the development of the principles of combined immunocorrection and the creation of a new approach - immunorehabilitation. The use of different immunomodulating preparations and antibiotics, hormones, cytostatics and other medicinal agents, having immunocorrecting properties is justified and sufficiently effective.