Sequentially photocleavable protecting groups in solid-phase synthesis.
Org Lett
; 5(8): 1179-81, 2003 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-12688713
ABSTRACT
[reaction see text] A sequential solid-phase peptide synthesis was developed using both photolabile linker and protecting groups. The chromatic sequential lability between a tert-butyl ketone-derived linker (sensitive to irradiation at 305 nm) and a nitroveratryloxycarbonyl (NVOC) group (sensitive at 360 nm) was exploited to prepare Leu-Enkephalin in a 55% overall yield. This new strategy allows the preparation of peptides in essentially neutral medium, by avoiding the use of common deprotection reagents such as trifluoroacetic acid or piperidine.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article