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Personality traits and striatal dopamine synthesis capacity in healthy subjects.
Laakso, Aki; Wallius, Esa; Kajander, Jaana; Bergman, Jörgen; Eskola, Olli; Solin, Olof; Ilonen, Tuula; Salokangas, Raimo K R; Syvälahti, Erkka; Hietala, Jarmo.
Afiliação
  • Laakso A; Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
Am J Psychiatry ; 160(5): 904-10, 2003 May.
Article em En | MEDLINE | ID: mdl-12727694
ABSTRACT

OBJECTIVE:

Neuroimaging and genetic studies suggest that individual differences in the brain dopaminergic system contribute to the normal variability of human personality (e.g., social detachment and novelty seeking). The authors studied whether presynaptic dopamine function is also associated with personality traits.

METHOD:

Presynaptic dopamine synthesis capacity in the brain was measured with positron emission tomography and [(18)F]fluorodopa in 33 healthy adults, and personality traits were assessed with the Karolinska Scales of Personality. Associations were studied by using a linear regression model controlling for the effects of age and gender on both variables.

RESULTS:

High scores on two of the anxiety-related personality scales, somatic anxiety and muscular tension, and on one aggressivity-related scale, irritability, were significantly associated with low [(18)F]fluorodopa uptake in the caudate. No statistically significant associations were observed between [(18)F]fluorodopa uptake and the detachment scale or scales related to novelty-seeking behavior (impulsiveness and monotony avoidance).

CONCLUSIONS:

The results suggest a role for the dopaminergic system in the regulation of anxiety in healthy subjects. Together with previous studies, they also indicate differential involvement of various components of the dopaminergic system in normal and pathological personality traits.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Personalidade / Determinação da Personalidade / Dopamina / Corpo Estriado Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2003 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Personalidade / Determinação da Personalidade / Dopamina / Corpo Estriado Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2003 Tipo de documento: Article