TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma.
Biochemistry (Mosc)
; 68(3): 346-8, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12733978
ABSTRACT
In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients. The average GSH, carnitine and TBARS levels for tumor group were respectively 7.11 +/- 3.3 micro g/mg protein, 1.81 +/- 0.39 nmol/mg protein, and 4.29 +/- 3.2 micro mol/mg protein, versus 14.45 +/- 4.11 micro g/mg protein, 2.14 +/- 0.66 nmol/mg protein, and 2.3 +/- 0.6 micro mol/mg protein for normal bladder tissues. Thus, tissue reduced glutathione levels (GSH) were significantly lower in patients as compared with the control group (p < 0.001) whereas average TBARS levels in the tumor group were found to be higher than those in control group. The average tissue carnitine levels in the patient group were found to be lower compared with the control group but the difference was not statistically significant (p > 0.05).
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Carnitina
/
Biomarcadores Tumorais
/
Substâncias Reativas com Ácido Tiobarbitúrico
/
Glutationa
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article