The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation.
Dev Cell
; 4(5): 711-26, 2003 May.
Article
em En
| MEDLINE
| ID: mdl-12737806
ABSTRACT
During meiosis, DNA replication is followed by two consecutive rounds of chromosome segregation. Cells lacking the protein phosphatase CDC14 or its regulators, SPO12 and SLK19, undergo only a single meiotic division, with some chromosomes segregating reductionally and others equationally. We find that this abnormal chromosome behavior is due to an uncoupling of meiotic events. Anaphase I spindle disassembly is delayed in cdc14-1, slk19Delta, or spo12Delta mutants, but the chromosome segregation cycle continues, so that both meiotic chromosome segregation phases take place on the persisting meiosis I spindle. Our results show that Cdc14, Slk19, and Spo12 are not only required for meiosis I spindle disassembly but also play a pivotal role in establishing two consecutive chromosome segregation phases, a key feature of the meiotic cell cycle.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Proteínas Fúngicas
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Proteínas Tirosina Fosfatases
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Proteínas de Ciclo Celular
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Segregação de Cromossomos
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Proteínas de Saccharomyces cerevisiae
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Meiose
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Proteínas Associadas aos Microtúbulos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article