Idebenone treatment in Friedreich's ataxia: neurological, cardiac, and biochemical monitoring.
Neurology
; 60(10): 1679-81, 2003 May 27.
Article
em En
| MEDLINE
| ID: mdl-12771265
ABSTRACT
The authors report 1-year prospective data on eight patients with Friedreich ataxia. Idebenone did not halt the progression of ataxia. At the end of therapy, cardiac ultrasound demonstrated significant reduction of cardiac hypertrophy in six of eight patients. Cardiac strain and strain rate imaging showed that the reduction of hypertrophy is preceded by an early and linear improvement in cardiac function. Idebenone reduced erythrocyte protoporphyrin IX levels in five of six patients with elevated baseline levels; however, changes did not consistently relate to cardiac improvement.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ataxia de Friedreich
/
Benzoquinonas
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Sequestradores de Radicais Livres
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Hipertrofia Ventricular Esquerda
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article