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Randomised trial: One cycle of anthracycline-containing adjuvant chemotherapy compared with six cycles of CMF treatment in node-positive, hormone receptor-negative breast cancer patients.
Ploner, F; Jakesz, R; Hausmaninger, H; Kolb, R; Stierer, M; Fridrik, M; Steindorfer, P; Gnant, M; Haider, K; Mlineritsch, B; Tschurtschenthaler, G; Steger, G; Seifert, M; Kubista, E; Samonigg, H.
Afiliação
  • Ploner F; Klinische Abteilung für Onkologie, Medizinische Universitätsklinik, Karl-Franzens-Universität Graz. ferdinand.ploner@kfunigraz.ac.at
Onkologie ; 26(2): 115-9, 2003 Apr.
Article em En | MEDLINE | ID: mdl-12771518
AIM: A randomised, controlled clinical trial was initiated in 1984 to test whether 1 cycle of anthracycline-containing adjuvant chemotherapy improves the outcome of breast cancer patients presenting with stage II disease and negative oestrogen and progesterone receptors (ER, PgR), as compared with 6 cycles of dose-reduced CMF. PATIENTS AND METHODS: Within 7 years 263 women with stage II breast cancer were randomised either to receive 1 cycle of doxorubicin, vinblastine, cyclophosphamide, methotrexate and 5- fluorouracil (AV-CMF) or to receive 6 cycles of cyclophosphamide, methotrexate and 5-fluorouracil (CMF). Patients were stratified for tumour stage, nodal stage, menopausal status, type of surgery and participating centre. RESULTS: After a median follow-up of 100 months, neither disease-free (DFS) nor overall survival (OS) differed significantly between the two groups. CONCLUSIONS: Compared to 6 cycles of a non-standard low-dose CMF regimen 1 cycle of anthracycline- containing adjuvant chemotherapy failed to improve the outcome in women with stage II receptor-negative breast cancer in terms of DFS and OS.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Protocolos de Quimioterapia Combinada Antineoplásica / Carcinoma Lobular / Carcinoma Ductal de Mama Tipo de estudo: Clinical_trials / Evaluation_studies Idioma: En Ano de publicação: 2003 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Protocolos de Quimioterapia Combinada Antineoplásica / Carcinoma Lobular / Carcinoma Ductal de Mama Tipo de estudo: Clinical_trials / Evaluation_studies Idioma: En Ano de publicação: 2003 Tipo de documento: Article