Differential molecular profiling between skin carcinomas reveals four newly reported genes potentially implicated in squamous cell carcinoma development.
Oncogene
; 22(22): 3500-5, 2003 May 29.
Article
em En
| MEDLINE
| ID: mdl-12776202
ABSTRACT
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are skin tumors with different invasive potential. In this work, we analysed mRNA differential expression between seven BCC and five SCC and their normal skin counterparts using 1176 cDNA macroarrays and verification by RT-PCR to identify genes modulated in each tumor type. We identified 37 genes commonly modulated in both tumors and four genes specifically modulated in SCC. Among these latter RhoC and EMMPRIN genes seem to be of particular interest and could participate in SCC aggressivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma de Células Escamosas
/
Regulação Neoplásica da Expressão Gênica
/
Transformação Celular Neoplásica
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article