Acute inflammation enhances substance P-induced plasma protein extravasation in the rat knee joint.
Regul Pept
; 39(2-3): 227-35, 1992 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-1279754
ABSTRACT
Acute inflammation of the rat knee joint was induced by intra-articular injection of 2% carrageenan. Intra-articular perfusion of the inflamed joint with substance P (SP) exacerbated the inflammatory condition as assessed by the degree of plasma protein extravasation into the synovial cavity. Protein extravasation induced by SP was enhanced and more persistent in the inflamed rat knee compared to normal animals. The time course of the response in the inflamed rat knee was related to SP concentration whilst the persistency of the response was positively correlated with the initial level of joint inflammation.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite
/
Proteínas Sanguíneas
/
Substância P
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article