B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.
J Exp Med
; 197(12): 1721-30, 2003 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-12810690
ABSTRACT
B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function of both members. Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, B7DC binds to PD-1(-/-) cells and enhances T cell killing in a PD-1-independent mechanism. Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Proteínas Sanguíneas
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Proteínas
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Antígeno B7-1
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Linfócitos T CD8-Positivos
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Neoplasias Experimentais
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Antígenos de Superfície
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article