Effectiveness of 2-step (consecutive) embryo transfer. Comparison with cleavage-stage transfer.
J Reprod Med
; 48(5): 370-4, 2003 May.
Article
em En
| MEDLINE
| ID: mdl-12815912
ABSTRACT
OBJECTIVE:
To evaluate the effectiveness of 2-step (consecutive) embryo transfer (ET), in which two cleaved embryos are transferred on day 2 (first step of ET) and a single blastocyst is transferred on day 5 (second step of ET) in comparison with conventional day 2 ET. STUDYDESIGN:
Observational comparative study at different time periods. Subjects were those who had > or = 4 embryos on day 2 after oocyte retrieval. Those in the conventional group (n = 60) received conventional day 2 ET, in which 3 cleaved embryos were transferred on day 2 between January 1999 and June 2000. Those in the 2-step group (n = 124) received 2-step embryo transfer, in which 2 cleaved embryos were transferred on day 2 and a blastocyst was transferred on day 5 between September 2000 and February 2002. Patients who planned to receive 2-step ET but could not proceed to the second step of ET because of failure to produce blastocysts were included in the 2-step group.RESULTS:
The ongoing pregnancy rate with 2-step ET (51.6%) was significantly higher than with conventional ET (26.7%) (P < .01). The clinical pregnancy rate and implantation rate in conventional and 2-step ET were 30.0% vs. 59.7% and 11.1% vs. 27.8%, respectively (P < .001).CONCLUSION:
Two-step ET may benefit patients who can obtain a sufficient number of embryos.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Blastocisto
/
Taxa de Gravidez
/
Transferência Embrionária
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article