Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models.
Eur J Neurosci
; 17(12): 2750-4, 2003 Jun.
Article
em En
| MEDLINE
| ID: mdl-12823482
ABSTRACT
Cannabinoids have been considered for some time as potent therapeutic agents in chronic pain management. Central and systemic administration of natural, synthetic and endogenous cannabinoids produce antinociceptive and antihyperalgesic effects in both acute and chronic animal pain models. Although much of the existing data suggest that the analgesic effects of cannabinoids are mediated via neuronal CB1 receptors, there is increasing evidence to support a role for peripheral CB2 receptors, which are expressed preferentially on immune cells. As yet, little is known about the central contribution of CB2 in neuropathic pain states. We report here that chronic pain models associated with peripheral nerve injury, but not peripheral inflammation, induce CB2 receptor expression in a highly restricted and specific manner within the lumbar spinal cord. Moreover, the appearance of CB2 expression coincides with the appearance of activated microglia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Receptores de Droga
/
Traumatismos da Medula Espinal
/
Proteínas Sanguíneas
/
Antígenos CD
/
Expressão Gênica
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Proteínas Aviárias
/
Receptor CB2 de Canabinoide
/
Antígenos de Neoplasias
/
Antígenos de Superfície
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article