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Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity.
Chaston, Timothy B; Richardson, Des R.
Afiliação
  • Chaston TB; Children's Cancer Institute Australia for Medical Research, The Iron Metabolism and Chelation Program, Randwick, Sydney, New South Wales, Australia.
Am J Hematol ; 73(3): 200-10, 2003 Jul.
Article em En | MEDLINE | ID: mdl-12827659
The success of the iron (Fe) chelator desferrioxamine (DFO) in the treatment of beta-thalassemia is limited by its lack of bioavailability. The design and characterization of synthetic alternatives to DFO has attracted much scientific interest and has led to the discovery of orally active chelators that can remove pathological Fe deposits. However, chelators that access intracellular Fe pools can be toxic by either inhibiting Fe-containing enzymes or promoting Fe-mediated free radical damage. Interestingly, toxicity does not necessarily correlate with Fe-binding affinity or with chelation efficacy, suggesting that other factors may promote the cytopathic effects of chelators. In this review, we discuss the interactions of chelators and their Fe complexes with biomolecules that can lead to toxicity and tissue damage.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quelantes de Ferro / Sobrecarga de Ferro / Ferro Limite: Humans Idioma: En Ano de publicação: 2003 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quelantes de Ferro / Sobrecarga de Ferro / Ferro Limite: Humans Idioma: En Ano de publicação: 2003 Tipo de documento: Article