The role of gene duplication in the evolution and function of the vertebrate Dlx/distal-less bigene clusters.
J Struct Funct Genomics
; 3(1-4): 151-9, 2003.
Article
em En
| MEDLINE
| ID: mdl-12836694
ABSTRACT
The Dlx gene family controls developmental patterning principally in the pharyngeal and cranial regions. We review the structure and function of these genes in the vertebrates and relate these properties to their evolution. We particularly focus on the Dlx3-7 bigene cluster which we postulate to be more derived phylogenetically and functionally than the other two bigene clusters, Dlx1-2 and Dlx5-6. We stress the transcriptional control of the Dlx3-7 bigene cluster, and postulate its control by Dlx1-2.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Família Multigênica
/
Proteínas de Homeodomínio
/
Evolução Molecular
/
Duplicação Gênica
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article