Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.
World J Gastroenterol
; 9(7): 1563-6, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12854164
ABSTRACT
AIM:
To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats.METHODS:
Hepatic/renal function, histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models.RESULTS:
Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group.CONCLUSION:
P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazinas
/
Traumatismo por Reperfusão
/
Sequestradores de Radicais Livres
/
Selectina-P
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article