Encephalitis complicating smallpox vaccination.
Arch Neurol
; 60(7): 925-8, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12873847
ABSTRACT
A smallpox vaccination program has been initiated. The vaccine is a live virus that was used in the last century. Postvaccinal encephalitis is a complication of this vaccine. The clinical presentation, course, neuroimaging findings, and spinal fluid abnormalities are similar to a disorder that physicians are familiar with, acute disseminated encephalomyelitis. This complication can be prevented with the administration of antivaccinia gamma globulin at the time of vaccination. Antivaccinia gamma globulin is not efficacious once this complication occurs. Intravenous methylprednisolone is the recommended therapy, although intravenous immunoglobulin and plasmapheresis should be investigated in the treatment of postvaccinal encephalitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacina Antivariólica
/
Encefalomielite Aguda Disseminada
Tipo de estudo:
Diagnostic_studies
/
Incidence_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article