Cell polarity: the ups and downs of the Par6/aPKC complex.
Curr Opin Genet Dev
; 13(4): 341-50, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12888006
ABSTRACT
A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
/
Transdução de Sinais
/
Polaridade Celular
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article