Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides.
Org Biomol Chem
; 1(4): 648-54, 2003 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-12929451
ABSTRACT
A novel series of mono and bisnaphthalimides was synthesized and their antiproliferative activities were evaluated against three tumor cell lines. Bisnaphthalimides 3 and 4, bearing a pyrazine ring fused to the naphthalimide system, showed activities in the order of 10(-8) microM, similar to elinafide. DNA binding properties and the ability to induce DNA damage were studied for some of the most active compounds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Naftalenos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article