ST-deviation reconstruction in missing leads on the 12-lead ECG: applicability in studies on ST-segment resolution during thrombolysis.
J Electrocardiol
; 36(3): 187-93, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12942480
ABSTRACT
Quantitative analysis of ST-segment deviations (STdev) and their resolution by treatment (STR; calculated from a combined sum of STdev in multiple leads) are used in trials on reperfusion for myocardial infarction (MI). Unreadable or unavailable electrocardiogram (ECG) leads are a common reason for exclusion, decreasing the statistical power of the trials. We developed mathematical formulas for reconstruction of immeasurable STdev based on STdev from other available leads on the 12-lead ECG. Formulas were deducted from a database of computer-assisted STdev measurements in 2 ECGs (baseline and 180 min after thrombolysis) of 1121 pts. Their accuracy was later evaluated on a second dataset of 377 pts. Acceptable fits could be derived for absent single leads, or for groups of absent limb leads (I-II-III or aVL-aVF). The intraclass correlation coefficient between real and calculated STdev was >or= 0.80 for each (0.77 for V1 in inferior MI). The correlations between STR calculated from original data and from reconstructed STdev were very strong (all intraclass correlation >or=0.97), and discordance in STR subgroup categorization occurred in
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eletrocardiografia
/
Infarto do Miocárdio
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article