Synthesis of substituted naphthalenes and carbazoles by the palladium-catalyzed annulation of internal alkynes.
J Org Chem
; 68(19): 7342-9, 2003 Sep 19.
Article
em En
| MEDLINE
| ID: mdl-12968885
ABSTRACT
An efficient synthesis of highly substituted naphthalenes has been developed by the palladium-catalyzed annulation of a variety of internal alkynes, in which two new carbon-carbon bonds are formed in a single step under relatively mild reaction conditions. This method has also been used to synthesize carbazoles, although a higher reaction temperature is necessary. The process involves arylpalladation of the alkyne, followed by intramolecular Heck olefination and double-bond isomerization. This method accommodates a variety of functional groups and affords the anticipated highly substituted naphthalenes and carbazoles in good to excellent yields.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article