Acute pericarditis and pleural effusion complicating cytarabine chemotherapy.
Onkologie
; 26(4): 348-50, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12972701
ABSTRACT
BACKGROUND:
Pericarditis is a rare but possibly severe complication of treatment of acute leukemia with cytarabine. CASE REPORT We report a possibly cytarabine-induced acute pericarditis and pleuritis with a rapid onset. A patient with acute myelomonocytic leukemia developed an isolated pericarditis 3 weeks after the first course of chemotherapy with cytarabine and idarubicin. The second course of chemotherapy with cytarabine and amsacrine was started after clinical improvement; 3 days later an acute pericarditis with a large pericardial effusion accompanied by a left pleural effusion developed. A pericardio- and pleuracentesis was performed and the symptoms improved rapidly without reaccumulation of the fluid. The third course of chemotherapy with mitoxantrone and etoposide was completed without further cardiopulmonary complications.CONCLUSION:
The differential diagnosis of pericarditis in the setting of chemotherapy with cytarabine should include cytarabine- induced pericarditis. The pathogenesis remains unclear, directly toxic and immunological mechanisms are suggested. Severe progression with massive pericardial effusion necessitating risky pericardiocentesis can occur and therefore a therapy with high-dose corticosteroids should be considered early.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pericardite
/
Derrame Pleural
/
Leucemia Mielomonocítica Aguda
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Citarabina
/
Antimetabólitos Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article