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Clinicopathological features in ovine AA amyloidosis.
Fernández, A; Ménsua, C; Biescas, E; Luján, L.
Afiliação
  • Fernández A; Department of Animal Pathology, University of Zaragoza, Veterinary Faculty, Miguel Servet 177, 50013 Zaragoza, Spain.
Res Vet Sci ; 75(3): 203-8, 2003 Dec.
Article em En | MEDLINE | ID: mdl-13129668
This paper describes the clinicopathological findings in sheep with AA amyloidosis. Serum samples from 12 AA amyloid-affected sheep and urine samples from 5 of these ewes were analyzed. In sera, the most important alteration was reflected in hypoalbuminemia, high concentration in beta and gamma-globulins and high levels of serum BUN, phosphorous and potassium. Serum creatinine, cholesterol and calcium concentrations showed no alterations. Urinary analysis showed proteinuria and a high protein/creatinine ratio. In three urine samples, high activities of urinary enzymes gamma-glutamyl transferase (GGT), beta-glucuronidase (GRS) and N-acetyl-beta-D-glucosaminidase (NAG) were observed, their ratios with urinary creatinine being increased for GGT and NAG and decreased for GRS. In conclusion, important alterations in biochemical and urinary parameters were observed in ovine affected by systemic AA amyloidosis. Those related to the activities of urinary enzymes could constitute reliable parameters for assessing renal injury in ovine AA amyloidosis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Ovinos / Amiloidose / Nefropatias Limite: Animals Idioma: En Ano de publicação: 2003 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Ovinos / Amiloidose / Nefropatias Limite: Animals Idioma: En Ano de publicação: 2003 Tipo de documento: Article