Identification of the major degradation products of 4-methoxy-2-(3-phenyl-2-propynyl)phenol formed by exposure to air and light.
J Pharm Sci
; 81(8): 812-4, 1992 Aug.
Article
em En
| MEDLINE
| ID: mdl-1328600
Exposure of 4-methoxy-2-(3-phenyl-2-propynyl)phenol (CO/1828) to air and light (accelerated by temperature) yields 1-(2-hydroxy-5- methoxyphenyl)-3-phenylpropynone as the major degradation product. With extraction, this product rapidly degrades to 5-methoxyaurone and 6-methoxyflavone. In addition, a mixture of dimeric and heterodimeric compounds that are not fully identified was observed. These results indicate the formation of a reactive ortho-quinone methide as an unstable intermediate. This hypothesis is supported by evidence that the aurone slowly isomerizes into the flavone in control samples. Identification of compounds was accomplished with mass spectrometry, nuclear magnetic resonance spectrometry, UV-high-performance liquid chromatography, and comparison with authentic samples.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Anti-Inflamatórios
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article