Characterization of the tachykinin NK2 receptor subtype in the rabbit pulmonary artery.
Peptides
; 13(2): 281-5, 1992.
Article
em En
| MEDLINE
| ID: mdl-1329043
ABSTRACT
Contractile responses to neurokinin A (NKA), neuropeptide gamma(NP gamma), and the NK2 receptor-selective analogs [Lys5,MeLeu9,Nle10]NKA(4-10) and MDL 28,564 were determined in the endothelium-denuded rabbit pulmonary artery. Responses to NKA, NP gamma, and [Lys5,MeLeu9,Nle10]NKA(4-10) were antagonized by the NK2 receptor antagonist MDL 29,913, with pA2 values of 6.67, 6.46, and 7.32, respectively. Autoradiographic studies failed to demonstrate any specific binding sites for [125I]-iodohistidyl NKA (INKA) over the pulmonary artery. These data suggest the presence in rabbit pulmonary artery of an unusual "nonclassical" NK2 receptor subtype, which appears to lack affinity for INKA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artéria Pulmonar
/
Taquicininas
/
Receptores de Neurotransmissores
/
Contração Muscular
/
Músculo Liso Vascular
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article