A study of chromosome 6 allele loss in human colorectal carcinomas.
Anticancer Res
; 12(5): 1717-9, 1992.
Article
em En
| MEDLINE
| ID: mdl-1332582
ABSTRACT
Matched normal/tumor DNA pairs from patients with sporadic and hereditary (FAP = familial adenomatous polyposis) colorectal carcinoma were examined for tumor-specific allele loss on chromosome 6 using cDNA probes for the avian myeloblastosis viral oncogene homologue (MYB on 6q22-q23), the estrogen receptor (ESR on 6q24-q27), and for the alpha polypeptide of human chorionic gonadotropin (CGA on 6q14-q21). No chromosome 6 allele loss was observed at these gene loci among 22 colorectal carcinomas examined, although such losses were relatively frequent (37.5% of informative individuals) at the D17S28 locus on chromosome 17. These results are consistent with karyological studies and indicate that chromosome 6 allele loss from colorectal carcinomas may occur less frequently than previously reported.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Cromossomos Humanos Par 6
/
Deleção Cromossômica
/
Neoplasias do Colo
/
Polipose Adenomatosa do Colo
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article