The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior.
J Neural Transm Gen Sect
; 87(1): 23-35, 1992.
Article
em En
| MEDLINE
| ID: mdl-1346965
ABSTRACT
The effects of competitive (CGP 37849 and CGP 39551) and non-competitive (dizocilpine) N-methyl-D-aspartate (NMDA) antagonists were tested in three animal models (catalepsy, sniffing, locomotion) and, in addition, the modulation of these effects by an agonist of the strychnine-insensitive glycine binding site was investigated. Both competitive and non-competitive NMDA antagonists reduced neuroleptic-induced catalepsy. Weak sniffing was induced by the competitive antagonist but strong sniffing by the non-competitive NMDA antagonist. Due to muscle relaxation the competitive antagonist reduced locomotion, in contrast to stimulation of locomotor activity induced by the non-competitive NMDA antagonist. The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Receptores de N-Metil-D-Aspartato
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article