DNA polymorphisms of the human CD46 gene in fetal and adult tissues.
J Reprod Immunol
; 21(2): 203-7, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1347788
ABSTRACT
DNA polymorphisms of the CD46 gene were investigated using a full length cDNA probe and five different restriction enzymes in genomic DNA samples from human fetal tissues and adult peripheral blood leukocytes. A HindIII polymorphism was observed and was classed as Types I, II and III at a ratio of approximately 3.521, depending on the presence or absence of two polymorphic fragments of 4.5 and 2.0 kb. No variation of polymorphic distribution was evident between the fetal and adult samples. Whether variation in CD46 expression between maternal and fetal tissue is relevant to fetal viability in pregnancy remains to be established.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
Glicoproteínas de Membrana
/
Antígenos CD
/
Feto
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article