In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat.
Brain Res
; 573(2): 345-8, 1992 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-1354551
ABSTRACT
Extracellular concentrations of gamma-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stages, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Aspártico
/
Ácido gama-Aminobutírico
/
Glutamatos
/
Hipocampo
/
Tonsila do Cerebelo
/
Excitação Neurológica
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article