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A study of bone formation in osteoma cutis employing biochemical, histochemical and in situ hybridization techniques.
Oikarinen, A; Tuomi, M L; Kallionen, M; Sandberg, M; Väänänen, K.
Afiliação
  • Oikarinen A; Department of Dermatology, University of Oulu, Finland.
Acta Derm Venereol ; 72(3): 172-4, 1992.
Article em En | MEDLINE | ID: mdl-1357850
ABSTRACT
A female presenting multiple osteoma cutis lesions without underlying endocrinological disturbance was studied. Histologically, lesions revealed true bone formation with multiple osteoblastic cells. This was confirmed by demonstrating high alkaline phosphatase activity and osteonectin expression in osteoma cutis lesions. Interestingly, tenascin and type III procollagen were in close association to bony lesions, indicating that these matrix proteins may be somehow involved in bone formation. In situ hybridization revealed fibroblastic cells around bony lesions, which actively deposited type I collagen and osteonectin. One of the activators of bone formation, TGF beta, was also present in some osteoblastic cells. The results thus indicate that in osteoma cutis, fibroblasts have the ability to differentiate into osteoblastic cells, which have some properties of osteoblasts, such as high alkaline phosphatase activity and a high expression of osteonectin.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoma / Neoplasias Cutâneas Limite: Adult / Female / Humans Idioma: En Ano de publicação: 1992 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoma / Neoplasias Cutâneas Limite: Adult / Female / Humans Idioma: En Ano de publicação: 1992 Tipo de documento: Article