[Interactions between GABAergic and cholinergic mechanisms involved in monocular optokinetic nystagmus in frogs]. / Interactions de mécanismes GABAergiques et cholinergiques impliqués dans le nystagmus optocinétique monoculaire de la grenouille.
C R Acad Sci III
; 315(6): 241-6, 1992.
Article
em Fr
| MEDLINE
| ID: mdl-1361421
ABSTRACT
The systemic administration of atropine, a muscarinic cholinergic antagonist, was found to suppress the Nasal-Temporal (N-T) component of the frog monocular optokinetic nystagmus (OKN), which had appeared following a prior injection of bicuculline and which does not exist in the normal animal. On the contrary, the administration of a nicotinic cholinergic antagonist (D-TC, alpha-BGT, Hexamethonium) following that of bicuculline has prolonged the duration of the induced N-T component. Thus, ACh was shown to attenuate or to reinforce the GABAergic inhibition of the N-T component through muscarinic receptors or nicotinic receptors respectively. These data point to the existence of strong interactions between these two neurotransmission systems involved in frog monocular OKN.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colina
/
Nistagmo Optocinético
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
Fr
Ano de publicação:
1992
Tipo de documento:
Article