Immunohistologic demonstration of myocardial proteins with applications.
Am J Clin Pathol
; 97(3): 376-80, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1371901
ABSTRACT
The authors used antibodies specific for creatine kinase MB isoenzyme (CK-MB) and myosin light chain-1 (MLC-1) for immunohistologic staining. At appropriate dilutions of antibody, frozen sections of human heart muscle were positive for both CK-MB and MLC-1, whereas sections of human skeletal muscle were negative for both proteins. Staining for both CK-MB and MLC-1 also was demonstrated in an immature teratoma. Furthermore, staining was localized to the rhabdomyosarcomatous elements within the teratoma; other components of the tumor did not stain for CK-MB or MLC-1. Biopsies of skeletal muscle revealed that regenerative, but not intact normal or degenerating, fibers also contained CK-MB and MLC-1. Immunohistologic stains for CK-MB and MLC-1 may be useful as tumor markers and as markers for regenerative muscle fibers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas Imunológicas
/
Proteínas Musculares
/
Miocárdio
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article