Styryl and azastyryl 1,3-benzazoles with antihelminthic activity.
Farmaco
; 47(4): 477-88, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1388595
ABSTRACT
New 2-benzylideneimino- and 2-styryl-1,3-benzimidazole and benzothiazole derivatives have been prepared and tested in vitro against Caenorhabditis elegans, and Heligmosomoides polygyrus, showing some of them, interesting properties as inhibitors, which were not observed in the complementary in vivo tests. In order to rationalize the activity, log P was measured for all compounds, and QSAR models were developed, allowing the optimisation of the in vitro activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estirenos
/
Benzimidazóis
/
Anti-Helmínticos
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article