[Studies on a serum factor inhibiting lactate dehydrogenase (LDH) activity in a patient's serum].
Rinsho Byori
; 40(9): 970-6, 1992 Sep.
Article
em Ja
| MEDLINE
| ID: mdl-1434034
ABSTRACT
We found extremely low activity of serum lactate dehydrogenase (LDH, EC. 1.1.1.27) in a 70-year-old female patient. The decrease of LDH activity was observed when the normal serum was incubated with the patient's serum. Inhibition rate of LDH activity by the patient's serum was higher at 4 degrees C than at 37 degrees C. The patient's serum inhibited both subunits of LDH, and inhibited more strongly the M-subunit than the H-subunit LDH isoenzymes. IgG (lambda type) in the patient's serum was found to be responsible for the inhibition of LDH activity. The mechanism why IgG inhibiting LDH activity developed in the patient's serum remain undetermined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
L-Lactato Desidrogenase
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
Ja
Ano de publicação:
1992
Tipo de documento:
Article