Haloperidol does not alter expression of ethanol-induced conditioned place preference.
Behav Brain Res
; 50(1-2): 1-5, 1992 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-1449638
ABSTRACT
A recent experiment (Risinger et al., Psychopharmacology, 107 (1992) 453-456) has shown that haloperidol does not prevent acquisition of ethanol-induced conditioned place preference, suggesting that dopaminergic mechanisms do not mediate the primary rewarding properties of ethanol. The present experiment examined whether haloperidol would prevent the expression of conditioned reward to ethanol-paired stimuli using the place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP). A different stimulus was paired with saline. Before preference testing, different groups received one of three doses of haloperidol (0, 0.05 or 0.1 mg/kg); ethanol was not given. Haloperidol produced a dose-dependent decrease in locomotor activity, but did not affect conditioned place preference. These results suggest that expression of ethanol-induced conditioned place preference is mediated by non-dopaminergic mechanisms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem por Associação
/
Meio Social
/
Condicionamento Clássico
/
Etanol
/
Haloperidol
/
Motivação
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article