[Immunological mechanisms of graft versus tumor effect].
Nihon Rinsho
; 61(9): 1495-502, 2003 Sep.
Article
em Ja
| MEDLINE
| ID: mdl-14515715
ABSTRACT
Lesson from hematopoietic stem cell transplantation demonstrated that donor immuno-surveillance system can eradicate tumor cells. This is so-call graft versus tumor(GVT) effect. Antigen presenting cells show peptide from minor antigen rather leukemic specific antigen in the context of major histocompatibility complex. The effector cells composed of CD8 T lymphocyte, CD4 T lymphocyte, natural killer cell and natural killer T cell. Death signal was transmitted from effector cells via granzyme/perforin system and FasL/Fas system, and recently TRAIL system seems most important for GVT effect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunologia de Transplantes
/
Efeito Enxerto vs Tumor
Limite:
Animals
/
Humans
Idioma:
Ja
Ano de publicação:
2003
Tipo de documento:
Article