Proliferative activity of neokyotorphin-related hemoglobin fragments in cell cultures.
Protein Pept Lett
; 10(4): 386-95, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-14529492
ABSTRACT
alpha-Hemoglobin fragments alpha-(133-141), alpha-(134-141), alpha-(135-141), alpha-(137-141), alpha-(134-140), alpha-(133-138), alpha-(134-140) and alpha-(137-138) stimulate L929 tumor cell proliferation, alpha-(134-141) being the most active. alpha-(134-141) stimulates proliferation of M3 melanoma cells, murine embryonic fibroblasts, primary cultures of red bone marrow and spleen cells. In L929 cells the effect of alpha-(134-141) is cell density independent; in M3 cells alpha-(137-141) and alpha-(134-141) are most active at density 10,000 cells/well (96 well plate) independently on FBS content.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Hemoglobinas
/
Endorfinas
/
Divisão Celular
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article