Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Mol Cell
; 12(2): 393-400, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-14536079
ABSTRACT
Loss-of-function alterations of INK4A are commonly observed in lymphoid malignancies, but are consistently absent in pre-B cell leukemias induced by the chimeric oncoprotein E2a-Pbx1 created by t(1;19) chromosomal translocations. We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the INK4A-ARF tumor suppressor locus. Bmi-1-deficient hematopoietic progenitors are resistant to transformation by E2a-Pbx1; however, the requirement for Bmi-1 is alleviated in cells deficient for both Bmi-1 and INK4A-ARF. Furthermore, the adverse effects of E2a-Pbx1 on pre-B cell survival and differentiation are partially bypassed by forced expression of p16(Ink4a). These results link E2a-Pbx1 with Bmi-1 on an oncogenic pathway that is likely to play a role in the pathogenesis of human lymphoid leukemias through downregulation of the INK4A-ARF gene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Células-Tronco Hematopoéticas
/
Proteínas Nucleares
/
Proteínas de Fusão Oncogênica
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Regulação da Expressão Gênica
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Proteínas Proto-Oncogênicas
/
Proteínas de Homeodomínio
/
Inibidor p16 de Quinase Dependente de Ciclina
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article