Mast cell-IgE-and mast cell-structural cell interactions in allergic airway disease.
Curr Drug Targets Inflamm Allergy
; 2(4): 303-12, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14561149
ABSTRACT
Allergic diseases like atopic rhinitis, bronchial asthma, and urticaria are prevalent and on the rise. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators like histamine, leukotrienes, and prostaglandins. On the other hand, T lymphocytes, basophils and eosinophils are thought to be responsible in inducing the late phase response. Yet, recent studies show that the mast cell cannot be simplistically assigned a role in the immediate phase allergic response, and that this cell plays a crucial role in ongoing allergic inflammation, including the development of hyper-responsiveness. In the present article, the author will try to discuss the integrated roles of mast cells in IgE-mediated allergic inflammation with specific emphasis on the roles of mast cell-IgE networking and mast cell-structural cell interactions in the late phase allergic response and chronic allergic inflammation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Hipersensibilidade
/
Mastócitos
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article